Hydrochloric Acid → HCID 50916664, Verbindung

HRID 389402Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 389402
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:14])[C:10]([F:13])([F:12])[F:11].[C:15]([O:21][C@H:22]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:23](Cl)=[O:24])(=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17].CN(C)C1C=CC=CC=1.Cl>ClCCl>[C:15]([O:21][C@H:22]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:23]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:14])[C:10]([F:13])([F:11])[F:12])=[O:24])(=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 949N,N-DimethylanilineHCID 109878821-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethanoneHCID 86649875HCID 86649875, Verbindung

Produkt 1

HCID 50916664HCID 50916664, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone (2, 5.0 g, 22.4 mmol) was dissolved in dichloromethane (50 mL) and (R)-2-chloro-2-oxo-1-phenylethyl pivalate (8.54 g, 33.5 mmol) was added. To this mixture N,N-dimethylaniline (2.8 mL, 22.4 mmol) was added. The reaction mixture was stirred at room temperature for 3 hours. The mixture was diluted with dichloromethane (50 mL), treated with 1N HCl, washed with brine and the organic layer was separated and evaporated to give (R)-2-(4-chloro-2-(2,2,2-trifluoroacetyl)-phenylamino)-2-oxo-1-phenylethyl pivalate (12) as an brown oil.

Aufarbeitung

  1. washwashed with brine
  2. customthe organic layer was separated
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5b5c4784445740aa8df28f90547d288d
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08378143B2

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