HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Hydroxide → (S)-(7-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Hydroxide | HCID 14797 | — |
| Edukt | 5-Bromo-2-[(2R)-oxiran-2-ylmethoxy]phenyl formate | HCID 54148805 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | (S)-(7-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol | HCID 23394142 | — |
Reaktionsschritte
Preparation according to Preparation 8 using 5-bromo-2-[(2R)-oxiran-2-ylmethoxy]phenyl formate (7.0 g, 25 mmol), dioxane (30 ml) and KOH (10%, 15 ml), stirred for 1 h. Purification on flash column chromatography (Isooctane/EtOAc). Crude yield: 3.7 g. MS m/z (rel. intensity, 70 eV) 245 (M+, 97) 244 (M+, bp), 189 (48), 188 (50) 79 (39).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08524766B2 |
| Quelldatensatz | uspto-grants-2013_09 |
| ORD ID | ord-e8b8ba4163e34860aa156c4fc4e5c70d |
| Quellennotiz | uspto-grants-2013_09 |