3-Chloropropionyl chloride → 3-Chloro-1-(4-(2,4,5-trimethylphenyl)piperazin-1-yl)propan-1-one
Reaktionsgleichung
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([CH3:9])=[CH:4][C:3]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.[Cl:16][CH2:17][CH2:18][C:19](Cl)=[O:20]>>[Cl:16][CH2:17][CH2:18][C:19]([N:13]1[CH2:12][CH2:11][N:10]([C:3]2[CH:4]=[C:5]([CH3:9])[C:6]([CH3:8])=[CH:7][C:2]=2[CH3:1])[CH2:15][CH2:14]1)=[O:20]Komponenten
3
Versuchsvorschrift
A target compound (925 mg, 3.137 mmol, 62.5%) was yielded as liquid in the same manner as Reference Example 13 by reacting 1-(2,4,5-trimethylphenyl)piperazine (1.03 g, 5.041 mmol) with 3-chloropropionyl chloride (484.9 mg, 5.041 mmol) and purifying by separation through column chromatography (EtOAc/hexane, 1:2).
Aufarbeitung
- custompurifying by separation through column chromatography (EtOAc/hexane, 1:2)