Trifluoroacetic acid → HCID 44818005, Verbindung
Reaktionsgleichung
CC([N:5]([CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:14]=[C:15]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[CH:26]=2)[C:16]2[C:22](=[O:23])[NH:21][CH:20]=[CH:19][C:17]=2[N:18]=1)C(=O)[O-])(C)C.C(O)(C(F)(F)F)=O>ClCCl>[NH2:5][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:14]=[C:15]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[CH:26]=2)[C:16]2[C:22](=[O:23])[NH:21][CH:20]=[CH:19][C:17]=2[N:18]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
1,1-dimethylethyl[3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]carbamate (245 mg, 0.577 mmol) was dissolved into dichloromethane (3 mL) and TFA (1 mL) was added. The reaction mixture was stirred for 1 h and concentrated. The residue was further dried under high vacuum to afford the product as a TFA salt (250 mg).