N-bromobutanimide → HCID 58296328, Verbindung

HRID 390062Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 390062
[CH3:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:10]3[C:20](=[O:21])[NH:19][CH:18]=[CH:17][C:11]=3[N:12]=[C:13]([S:15][CH3:16])[N:14]=2)[CH:5]=[CH:6][CH:7]=1.C1C(=O)N([Br:29])C(=O)C1>CN(C)C=O>[Br:29][C:17]1[C:11]2[N:12]=[C:13]([S:15][CH3:16])[N:14]=[C:9]([NH:8][C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[CH:3]=3)[C:10]=2[C:20](=[O:21])[NH:19][CH:18]=1

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 58296312HCID 58296312, Verbindung

Produkt 1

HCID 58296328HCID 58296328, VerbindungAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-[(3-methylphenyl)amino]-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one (500 mg, 1.676 mmol) was dissolved into N,N-Dimethylformamide (DMF) (8 mL) and NBS (298 mg, 1.676 mmol) was added. The reaction mixture was stirred at rt for 2 h. It was quenched with water (12 mL) and EtOAc (5 mL) was added. The mixture was filtered to collect the precipitate, which was further dried under high vacuum to give 470 mg of crude product (83% pure based on LC-MS).

Aufarbeitung

  1. additionwas added
  2. customIt was quenched with water (12 mL) and EtOAc (5 mL)
  3. additionwas added
  4. filtrationThe mixture was filtered
  5. customto collect the precipitate, which
  6. customwas further dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-73345933f8024366b423f3153a7150da
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08383635B2

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