2-cyano-N-cyclohexyl-N-methylacetamide → 3-Amino-N-cyclohexyl-N-methyl-propionamide

HRID 390194Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 390194
[C:1]([CH2:3][C:4]([N:6]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[CH3:7])=[O:5])#[N:2].[H][H]>[Ni].N.CO>[NH2:2][CH2:1][CH2:3][C:4]([N:6]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[CH3:7])=[O:5]

Komponenten

5

Edukt 2

HCID 247058332-cyano-N-cyclohexyl-N-methylacetamideHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 167934313-Amino-N-cyclohexyl-N-methyl-propionamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 21705897Ammonia methanolLösungsmittel

Versuchsvorschrift

A mixture of 2-cyano-N-cyclohexyl-N-methyl-acetamide (3.96 g, 0.022 mol), a known compound, (which may be prepared as disclosed in Osdene, Thomas S. et al. Journal of Medicinal Chemistry (1967), 10(2), 165-7; Osdene, Thomas S.; Santilli, Arthur A. U.S. Pat. No. 3,138,595) and Raney nickel (3 g) in NH3/MeOH (300 mL) was hydrogenated at normal pressure. After 2 equivalents of hydrogen were consumed, the catalyst was removed by filtration. The filtrate was evaporated, and toluene was added to the residue and then evaporated to yield a residue.

Aufarbeitung

  1. customa known compound, (which may be prepared
  2. customthe catalyst was removed by filtration
  3. customThe filtrate was evaporated
  4. additiontoluene was added to the residue
  5. customevaporated
  6. customto yield a residue

Quellen und Nachweise

ORD-Eintrag
ord-0bf6a6dd20ba4f1b935acb9e65d733d7
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08383637B2

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