HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ammonia → 3-(5-Fluoropyridin-3-yl)-5-(3-(trifluoromethyl)phenyl)isoxazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ammonia | HCID 222 | — |
| Edukt | 1-Ethynyl-3-(trifluoromethyl)benzene | HCID 2778490 | — |
| Edukt | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| Produkt | 3-(5-Fluoropyridin-3-yl)-5-(3-(trifluoromethyl)phenyl)isoxazole | HCID 44546353 | — |
Reaktionsschritte
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 1-ethynyl-3-(trifluoromethyl)benzene (Aldrich, 85 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.57 (s, 1H), 7.71-7.96 (m, 2H), 8.09-8.32 (m, 3H), 8.62 (d, J=2.7 Hz, 1H), 8.98 (t, J=1.5 Hz, 1H) ppm; MS (DCI/NH3) m/z 309 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08383658B2 |
| Quelldatensatz | uspto-grants-2013_02 |
| ORD ID | ord-d8b94b468e774774afcaa0dddf43ad29 |
| Quellennotiz | uspto-grants-2013_02 |