(6-Iodopyridin-3-yl)methanol → 6-Iodopyridine-3-carbaldehyde

HRID 390596Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 390596
[I:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=1>ClCCl.[O-2].[Mn+2]>[I:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 23039516(6-Iodopyridin-3-yl)methanol

Produkt 1

HCID 534852236-Iodopyridine-3-carbaldehydeAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 160959Manganese oxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

86 g (987 mol) of manganese (II) oxide are added to a solution of 23.2 g (98.7 mmol) of (6-iodopyrid-3-yl)methanol in 800 mL of dichloromethane. The reaction mixture is stirred at room temperature for 22 hours. The reaction mixture is filtered through Celite and rinsed with dichloromethane. The filtrate is evaporated under vacuum to give 17 g (74%) of 6-iodopyridine-3-carbaldehyde in the form of a yellow solid.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered through Celite
  2. washrinsed with dichloromethane
  3. customThe filtrate is evaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-59f54983381a4a138629797dbf0435ea
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08383652B2

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