HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetic Anhydride → 2-Acetamidopyridine-5-boronic acid pinacol ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetic Anhydride | HCID 7918 | — |
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine | HCID 2756555 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 2-Acetamidopyridine-5-boronic acid pinacol ester | HCID 17750202 | — |
Reaktionsschritte
To 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (120 mg) in dry DCM (3 ml) and triethylamine (1.5 equiv., 114 uL) was added acetic anhydride (1.1 equiv., 57ul) and the reaction mixture was stirred at room temperature overnight. Dichloromethane/brine extraction and purification on silica gave 66 mg of N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-yl]-acetamide.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08383620B2 |
| Quelldatensatz | uspto-grants-2013_02 |
| ORD ID | ord-2941b3bf7cfa4cc6a87b286261c30b3a |
| Quellennotiz | uspto-grants-2013_02 |