Thionyl Chloride → 2,3-Dihydro-benzo[b]oxepine-4-carbonylchloride

HRID 391277Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 391277
[O:1]1[CH2:7][CH2:6][C:5]([C:8](O)=[O:9])=[CH:4][C:3]2[CH:11]=[CH:12][CH:13]=[CH:14][C:2]1=2.S(Cl)([Cl:17])=O>O1CCCC1>[O:1]1[CH2:7][CH2:6][C:5]([C:8]([Cl:17])=[O:9])=[CH:4][C:3]2[CH:11]=[CH:12][CH:13]=[CH:14][C:2]1=2

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 11116823HCID 11116823, Verbindung

Produkt 1

HCID 866497862,3-Dihydro-benzo[b]oxepine-4-carbonylchloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2,3-Dihydro-benzo[b]oxepine-4-carboxylicacid (2.3 mmol) was dissolved in 15 ml tetrahydrofuran. 0.7 ml of thionylchloride were added dropwise and the solution was stirred for two hours. The reaction was quenched by methanol. Methanol and thionylchloride were removed in vacuo yielding 340 mg of 2,3-Dihydro-benzo[b]oxepine-4-carbonylchloride. This was used for step E without further purification.

Aufarbeitung

  1. customThe reaction was quenched by methanol
  2. customMethanol and thionylchloride were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-51f21275dd8f428581af85e507df0333
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08383838B2

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