Potassium Carbonate → Methyl 2-methoxy-5-(2-methyl-2H-tetrazol-5-yl)benzoate

HRID 391395Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 391395
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[NH:17][N:16]=[N:15][N:14]=2)=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[C:18](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[N:15][N:16]([CH3:18])[N:17]=2)=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6]

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 178497409HCID 178497409, Verbindung

Produkt 1

HCID 58993674Methyl 2-methoxy-5-(2-methyl-2H-tetrazol-5-yl)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Methyl 2-methoxy-5-(1H-tetrazol-5-yl)benzoate (0.78 g, 3.33 mmol) methyl iodide (0.21 mL, 3.33 mmol) and potassium carbonate (0.46 g, 3.33 mmol) were combined in acetone (8 mL) and heated at reflux overnight. After cooling to room temperature, the mixture was filtered and concentrated. Flash chromatography on silica gel afforded 170 mg (21%). LC/MS (HPLC method 3): tR=2.01 min, 249.09 (MH)+

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux overnight
  3. filtrationthe mixture was filtered
  4. concentrationconcentrated
  5. customFlash chromatography on silica gel afforded 170 mg (21%)

Quellen und Nachweise

ORD-Eintrag
ord-b5e80164e3ea40a7a1227abdfed18de3
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08383821B2

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