(Diethylamino)trimethylsilane → (S)-trimethyl{[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}silane

HRID 391566

Reaktionsgleichung

Reaktionsgleichung von HRID 391566
[CH3:1][S@:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[NH:4])=[O:3].[CH3:11][Si:12](N(CC)CC)([CH3:14])[CH3:13]>C(#N)C>[CH3:11][Si:12]([CH3:14])([CH3:13])[N:4]=[S@@:2]([CH3:1])(=[O:3])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Komponenten

4

Edukt 2

HCID 70454(Diethylamino)trimethylsilane2×HCID 25036288(S)-(+)-S-Methyl-S-phenylsulfoximine

Produkt 1

HCID 25041124(S)-trimethyl{[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}silane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

To a stirred pre-warmed solution of (S)-(+)-S-methyl-S-phenylsulphoximine (3 g, 18.7 mmol) in acetonitrile (2 mL) at 65° C. was added (trimethylsilyl)diethylamine (4.12 g, 21.1 mmol) dropwise via a syringe. The reaction was maintained at 65° C. and stirred for 3 hours. Additional amount of (trimethylsilyl)diethylamine (2 mL, 10.2 mmol) was added and the reaction mixture was stirred at 65° C. overnight. The reaction was then concentrated under reduced pressure and dried under vacuum to give the title compound. This material was used directly in next step of the synthesis without further purification.

Aufarbeitung

  1. stirringthe reaction mixture was stirred at 65° C. overnight
  2. concentrationThe reaction was then concentrated under reduced pressure
  3. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-8440d5b05f374f379ffa4ec1ef4a9cee
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08383825B2

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