Thionyl Chloride → HCID 10879289, Verbindung

HRID 392060Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 392060
[CH:1]1[C:14]2[N:13]([CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)S[C:5]=2[CH:4]=[CH:3][CH:2]=1.N=CCCC(CC1C=CC=CC=1)(CC1C=CC=CC=1)O.S(Cl)(Cl)=O>C1C=CC=CC=1>[C:12]1([N:13]([C:14]2[CH:1]=[CH:2][CH:3]=[CH:4][CH:5]=2)[CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Komponenten

5

Edukt 3

HCID 24386Thionyl ChlorideHCID 1114022010H-Phenothiazine-10-butanolHCID 22662683HCID 22662683, Verbindung

Produkt 1

HCID 10879289HCID 10879289, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To prepare compounds 6a, 6b and 6e, to a solution of 5a (2.03 g, 7.5 mmol), 5b or 5e in 100 ml of dry benzene was added thionyl chloride (2 ml, 10 mmol) and stirred overnight at room temperature. After solvent evaporation, the residue was chromatographed on silica gel column. Elution with 10% ethyl acetate/hexanes afforded the following compounds:

Aufarbeitung

  1. customAfter solvent evaporation
  2. customthe residue was chromatographed on silica gel column
  3. washElution with 10% ethyl acetate/hexanes
  4. customafforded the following compounds

Quellen und Nachweise

ORD-Eintrag
ord-735e3cac9b934c0f8773f833d4f12b59
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06800618B2

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