Dichloromethane → HCID 69921427, Verbindung

HRID 392061Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 392061
N=CCCC[C:6]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11]C=1)O.[NH:22]=[CH:23][CH2:24][CH2:25][CH2:26]CC(CC1C=CC=CC=1)(CC1C=CC=CC=1)O.C1(N(C2C=CC=CC=2)CCCCO)C=CC=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(Cl)[Cl:82]>>[Cl:82][CH2:26][CH2:25][CH2:24][CH2:23][N:22]=[C:12]1[CH:11]=[C:8]([CH:6]=[CH:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:9]=[CH:14][CH2:13]1

Komponenten

6

Edukt 5

HCID 6344DichloromethaneHCID 11776TriphenylphosphineHCID 10879289HCID 10879289, VerbindungHCID 22662697HCID 22662697, VerbindungHCID 22662698HCID 22662698, Verbindung

Produkt 1

HCID 69921427HCID 69921427, Verbindung

Versuchsvorschrift

To prepare compounds 6c, 6d and 6f to a cooled 25 ml round-bottomed flask containing 5c (50 mg, 0.16 mmol), 5d or 5f and Ph3P (51 mg, 0.2 mmol) was added HCA (0.05 ml, 0.3 mmol) in 1 ml CH2Cl2. The reaction mixture was allowed to come to room temperature and stirred overnight. Flash silica gel column chromatography by eluting with hexane to remove the HCA followed by 5% ethyl acetate/hexanes afforded the following compounds:

Aufarbeitung

  1. customto come to room temperature
  2. washFlash silica gel column chromatography by eluting with hexane
  3. customto remove the HCA
  4. customafforded the following compounds

Quellen und Nachweise

ORD-Eintrag
ord-34e96af856384c08becb80727db9a761
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06800618B2

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