HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium ethoxide → 4-Azaindole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium ethoxide | HCID 2723922 | — |
| Edukt | 2,2,2-trifluoro-N-(2-trimethylsilanylethynylpyridin-3-yl)acetamide | HCID 12146853 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 4-Azaindole | HCID 9226 | — |
Reaktionsschritte
A mixture of 2,2,2-trifluoro-N-(2-trimethylsilanylethynylpyridin-3-yl)acetamide (1.0 eq) and sodium ethoxide (5 eq.) in ethanol is heated at reflux temperature for 10 h, cooled and concentrated in vacuo. The resultant residue is purified by preparative reverse phase HPLC to give the title 4-azaindole.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06800640B2 |
| Quelldatensatz | uspto-grants-2004_10 |
| ORD ID | ord-2930650ca1d249b885405ad26de4d25a |
| Quellennotiz | uspto-grants-2004_10 |