HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Thiazolidine → 2-Difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Thiazolidine | HCID 10444 | — |
| Edukt | 2-Cyano-3-difluoromethoxyphenylsulfonyl chloride | HCID 58100767 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-Difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile | HCID 44199441 | — |
Reaktionsschritte
54 mg of 2-cyano-3-difluoromethoxy-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 32 I of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by HPLC affords 35 mg of 2-difluoromethoxy-6-(thiazolidine-3-sulfonyl)-benzonitrile.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08524896B2 |
| Quelldatensatz | uspto-grants-2013_09 |
| ORD ID | ord-4e03c46cba5d4544802825dfbdd6204e |
| Quellennotiz | uspto-grants-2013_09 |