Trifluoroacetic acid → 2-Oxoethyl butyrate

HRID 39253

Reaktionsgleichung

Reaktionsgleichung von HRID 39253
[C:1]([O:6][CH2:7][CH:8](OC)[O:9]C)(=[O:5])[CH2:2][CH2:3][CH3:4].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([O:6][CH2:7][CH:8]=[O:9])(=[O:5])[CH2:2][CH2:3][CH3:4]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 113673002,2-Dimethoxyethyl butyrate

Produkt 1

HCID 98988312-Oxoethyl butyrate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Compound 43a (176 mg, 1.0 mmol) was dissolved in 8 mL of CH2Cl2 and 4 mL of TFA (containing 5% H2O) was added. The mixture was stirred for 30 min at room temperature. The solution was then concentrated in vacuo to give the product 44a that was used immediately for the next step. 1H NMR (400 MHz, CDCl3) δ 0.92 (m, 3H), 1.64 (m, 2H), 2.24 (t, J=7.04 Hz, 2H), 4.72 (s, 2H), 9.60 (s, 1H).

Aufarbeitung

  1. concentrationThe solution was then concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8994c8ce8da447d3a3b5ecdf901c759e
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524691B2

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