Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 1-Methylpiperazine | HCID 53167 | — |
| Edukt | 5-Fluoro-2-nitrobenzonitrile | HCID 3756467 | — |
| Lösungsmittel | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Produkt | HCID 16102059 | HCID 16102059 | — |
Reaktionsschritte
5-Fluoro-2-nitrobenzenecarbonitrile (1.02 eq) and N-methylpiperazine (1.0 eq) were dissolved in NMP. Triethylamine (2.1 eq) was added, and the resulting solution heated at 100° C. for 1 hour. The solution was cooled to room temperature and poured into H2O. A precipitate formed which was filtered to yield the desired product as a green solid. LC/MS m/z 247.3 (MH+), Rf 1.46 minutes.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06800760B2 |
|---|
| Quelldatensatz | uspto-grants-2004_10 |
|---|
| ORD ID | ord-10331d7b06ab4f1f8d03168a7f651bd0 |
|---|
| Quellennotiz | uspto-grants-2004_10 |
|---|
