Water → HCID 16102059, Verbindung

HRID 392608

Reaktionsgleichung

Reaktionsgleichung von HRID 392608
F[C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([C:8]#[N:9])[CH:7]=1.[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(N(CC)CC)C.O>CN1C(=O)CCC1>[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([C:2]2[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([C:8]#[N:9])[CH:7]=2)[CH2:16][CH2:15]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 531671-MethylpiperazineHCID 37564675-Fluoro-2-nitrobenzonitrile

Produkt 1

HCID 16102059HCID 16102059, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

5-Fluoro-2-nitrobenzenecarbonitrile (1.02 eq) and N-methylpiperazine (1.0 eq) were dissolved in NMP. Triethylamine (2.1 eq) was added, and the resulting solution heated at 100° C. for 1 hour. The solution was cooled to room temperature and poured into H2O. A precipitate formed which was filtered to yield the desired product as a green solid. LC/MS m/z 247.3 (MH+), Rf 1.46 minutes.

Aufarbeitung

  1. temperatureThe solution was cooled to room temperature
  2. customA precipitate formed which
  3. filtrationwas filtered

Quellen und Nachweise

ORD-Eintrag
ord-10331d7b06ab4f1f8d03168a7f651bd0
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06800760B2

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