Ethyl Bromide → 2-Ethoxybenzonitrile
Reaktionsgleichung
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[CH3:17]>CC(C)=O>[CH2:16]([O:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH3:17]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
25 g (210 mmol) of 2-hydroxylbenzonitrile are heated, together with 87 g of potassium carbonate and 34.3 g (314.8 mmol) of ethyl bromide, in 500 ml of acetone under reflux overnight. The solid is filtered off, the solvent is removed in vacuo and the residue is distilled in vacuo. 30.0 g (97%) of a colorless liquid are obtained.
Aufarbeitung
- temperatureunder reflux overnight
- filtrationThe solid is filtered off
- customthe solvent is removed in vacuo
- distillationthe residue is distilled in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-30b68248ac194f4d8f029f3184997133
- Quelldatensatz
- uspto-grants-2004_10
- Patentnummer
- US06803365B2
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