Ethyl Bromide → 2-Ethoxybenzonitrile

HRID 392662

Reaktionsgleichung

Reaktionsgleichung von HRID 392662
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[CH3:17]>CC(C)=O>[CH2:16]([O:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH3:17]

Komponenten

5

Edukt 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 119072-Hydroxybenzonitrile

Produkt 1

HCID 5769222-EthoxybenzonitrileAusbeute 97,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

25 g (210 mmol) of 2-hydroxylbenzonitrile are heated, together with 87 g of potassium carbonate and 34.3 g (314.8 mmol) of ethyl bromide, in 500 ml of acetone under reflux overnight. The solid is filtered off, the solvent is removed in vacuo and the residue is distilled in vacuo. 30.0 g (97%) of a colorless liquid are obtained.

Aufarbeitung

  1. temperatureunder reflux overnight
  2. filtrationThe solid is filtered off
  3. customthe solvent is removed in vacuo
  4. distillationthe residue is distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-30b68248ac194f4d8f029f3184997133
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06803365B2

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