Toluene → 4-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester chloroformate

HRID 39290

Reaktionsgleichung

Reaktionsgleichung von HRID 39290
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(Cl)([Cl:17])=O.C1(C)C=CC=CC=1>C1COCC1>[Cl:17][C:6]([OH:5])=[O:7].[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Komponenten

5

Edukt 3

HCID 1140TolueneHCID 6371PhosgeneHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Produkt 1

HCID 866555934-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester chloroformate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (201 mg, 1.0 mmol) in THF (2 mL) was added a 20% solution of phosgene in toluene (358 μL, 1.7 mmol). The reaction was stirred at room temperature for 1 hour. The reaction was concentrated under reduced pressure.

Aufarbeitung

  1. concentrationThe reaction was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b8798188cd69492386d462f7445ecae2
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524764B2

Verknüpfte Notizen

Wird geladen…