HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methylamine → 7-Chloro-N-methyl-5-[(phenylmethyl)thio]-thiazolo[4 5-d]pyrimidin-2-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methylamine | HCID 6329 | — |
| Edukt | 5-(Benzylthio)-2-bromo-7-chlorothiazolo[4,5-d]pyrimidine | HCID 22052038 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 7-Chloro-N-methyl-5-[(phenylmethyl)thio]-thiazolo[4 5-d]pyrimidin-2-amine | HCID 22649116 | — |
Reaktionsschritte
A solution of the product from Example 219 (0.3 g) in tetrahydrofuran (2 ml) containing methylamine (2.0 molar in THF: 0.81 ml) was stirred for 16 hours. The mixture was evaporated to dryness then purified (SiO2, ethyl acetate:dichloromethane 1:9 as eluant) to give the title compound (295 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06806273B1 |
| Quelldatensatz | uspto-grants-2004_10 |
| ORD ID | ord-b015c6be86a4456390b77af240e36bd0 |
| Quellennotiz | uspto-grants-2004_10 |