Sulfuric Acid → HCID 22649192, Verbindung

HRID 393244Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 393244
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([OH:14])[CH:3]=1.S(=O)(=O)(O)[OH:16]>>[NH2:1][C:2]1[C:11]([C:12](=[O:16])[NH2:13])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([OH:14])[CH:3]=1

Komponenten

3

Edukt 2

HCID 1118Sulfuric AcidHCID 12486470Methyl 4-amino-5-cyano-2-hydroxybenzoate

Produkt 1

HCID 22649192HCID 22649192, Verbindung

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Methyl 4-amino-5-cyano-2-hydroxybenzoate (J. Chem. Soc. Perkin I. 1979, 677; 4 g) was added to stirred concentrated sulphuric acid (6 ml) and the mixture was heated to 80° C. for 30 minutes. The mixture was cooled to ambient temperature and poured onto crushed ice. The resultant solid was filtered off, washed well with water and dried to give methyl 4-amino-5-carbamoyl-2-hydroxybenzoate (2.8 g); NMR Spectrum: (DMSOd6) 3.83 (s, 3H), 6.1 (s, 1H), 6.75 (br m, 2H), 8.08 (s, 1H).

Aufarbeitung

  1. temperatureThe mixture was cooled to ambient temperature
  2. additionpoured
  3. customonto crushed ice
  4. filtrationThe resultant solid was filtered off
  5. washwashed well with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d5a0c989d63048798b83b9af9e2dfab8
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06806274B1

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