3-(Trifluoromethyl)aniline → Diethyl ((alpha,alpha,alpha-trifluoro-m-toluidino)methylene)malonate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Under a nitrogen atmosphere, a mixture of 3-(trifluoromethyl)aniline (40 mL, 0.32 mmol) and diethyl ethoxymethylmalonate was heated at 100° C. for 3 hours. The reaction mixture was allowed to cool to room temperature at which time the solution solidified to provide 102 g of diethyl 2-{[3-(trifluoromethyl)anilino]methylene}malonate as a cream colored solid.

Herkunft & Nachweise