Sodium Hydroxide → Ethyl (3S)-piperidine-3-carboxylate

HRID 394046

Reaktionsgleichung

Reaktionsgleichung von HRID 394046
C(O)(=O)[C@H]([C@@H](C(O)=O)O)O.[NH:11]1[CH2:16][CH2:15][CH2:14][C@H:13]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12]1.[OH-].[Na+]>>[NH:11]1[CH2:16][CH2:15][CH2:14][C@H:13]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12]1

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 14183617Ethyl (S)-3-Piperidinecarboxylate D-Tartrate

Produkt 1

HCID 187784Ethyl (3S)-piperidine-3-carboxylateAusbeute 112,8 %

Versuchsvorschrift

To 13.0 g of ethyl (3S)-3-piperidinecarboxylate D(−)-tartarate which was synthesized following the method of P. Magnus, et al. [J. Org. Chem. Vol. 56, 1166-1170 (1991)], 3N aqueous sodium hydroxide solution was added to render the former basic, followed by extraction with chloroform and drying over anhydrous magnesium sulfate. Distilling the solvent off under reduced pressure, 7.50 g of the title compound was obtained.

Aufarbeitung

  1. extractionfollowed by extraction with chloroform
  2. dry with materialdrying over anhydrous magnesium sulfate
  3. distillationDistilling the solvent off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2634489c1dd6442fbb237c8936f4cd17
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06809108B1

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