Hydrochloric Acid → 4-(Pyrrolidin-1-yl)tetrahydro-2H-pyran-3-amine dihydrochloride

HRID 39422

Reaktionsgleichung

Reaktionsgleichung von HRID 39422
C(OC(=O)[NH:7][C@H:8]1[C@H:13]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[CH2:12][CH2:11][O:10][CH2:9]1)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[N:14]1([CH:13]2[CH2:12][CH2:11][O:10][CH2:9][CH:8]2[NH2:7])[CH2:15][CH2:16][CH2:17][CH2:18]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 67358972HCID 67358972, Verbindung2×

Produkt 1

HCID 673600044-(Pyrrolidin-1-yl)tetrahydro-2H-pyran-3-amine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

trans-(4-Pyrrolidin-1-yl-tetrahydro-pyran-3-yl)-carbamic acid tert-butyl ester (intermediate H, 345 mg, 1.28 mmol) was dissolved in 6.4 mL dioxane. Hydrochloric acid (4N in dioxan, 3.2 mL, 13 mmol) was added. The reaction mixture was stirred at room temperature for 3 h. The solvent was evaporated off. The crude material, light brown solid (378 mg, >100%), MS: m/e=171.2 [(M+H)+] was used without further purification.

Aufarbeitung

  1. customThe solvent was evaporated off
  2. customThe crude material, light brown solid (378 mg, >100%), MS: m/e=171.2 [(M+H)+] was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-fea28dbce15a4b2aa7955dfd9fe63643
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524909B2

Verknüpfte Notizen

Wird geladen…