Iodine → 2-(4-Bromo-2-chlorophenyl)-1,3-oxazole

To a stirred solution of 4-bromo-2-chloro-N-(2-oxoethyl)benzamide (1.00 g, 3.617 mmol) in CH2Cl2 (30 mL) were added triphenylphosphine (1.90 g, 7.234 mmol), iodine (1.84 g, 7.234 mmol) and triethylamine (2.0 mL, 14.47 mmol) at room temperature. After 24 hour, the mixture was washed with water (20 mL), dried over MgSO4. Removal of the solvent, gave an oily recidue, which was purified by flash chromatography eluting with ethyl acetate/hexane (1/5) to give title compound (0.185 g, 20% yield).

1. washthe mixture was washed with water (20 mL)
2. dry with materialdried over MgSO4
3. customRemoval of the solvent
4. customgave an oily recidue, which
5. customwas purified by flash chromatography
6. washeluting with ethyl acetate/hexane (1/5)

ORD-Eintrag

ord-28f5235f7fd94425bacb3390a13fa483

Quelldatensatz

uspto-grants-2003_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06603008B1