Reaktionsgleichung
FC(F)(F)C([N:5]1[CH2:15][CH:14]2[CH2:16][CH:7]([C:8]3[CH:9]=[C:10]([NH2:18])[C:11]([OH:17])=[CH:12][C:13]=32)[CH2:6]1)=O.[C:21]([Cl:26])(=O)[CH:22]([CH3:24])[CH3:23]>>[ClH:26].[CH:22]([C:24]1[O:17][C:11]2[C:10]([N:18]=1)=[CH:9][C:8]1[CH:7]3[CH2:16][CH:14]([CH2:15][NH:5][CH2:6]3)[C:13]=1[CH:12]=2)([CH3:23])[CH3:21]Komponenten
3
Versuchsvorschrift
2,2,2-Trifluoro-1-(4-hydroxy-5-amino-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-ethanone and isobutyryl chloride were converted to the title compound following the procedures described in Example 47. (TLC 25% ethyl acetate/hexanes Rf 0.14). 1H NMR (400 MHz, CD3OD) δ 7.65 (2H), 3.49 (br s, 2H), 3.41 (d, J=12.0 Hz, 2H), 3.33-3.19 (3H), 2.45 (m, 1H), 2.18 (d, J=11.5 Hz, 1H), 1,45 (d, J=7.0 Hz, 6H). APCI MS m/e 243.2 [(M+1)+]. (HCl salt) M.p. 249-251° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-6ad9d182c88a4429a63337112c7541fc
- Quelldatensatz
- uspto-grants-2003_08
- Patentnummer
- US06605610B1
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