HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 395333Erstellt: 27. Oktober 2026
Water → 5-(4-Methylpiperazinyl)-2-nitrobenzenecarbonitrile
https://huagongshe.com/reaction/395333
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 1-Methylpiperazine | HCID 53167 | — |
| Edukt | 5-Fluoro-2-nitrobenzonitrile | HCID 3756467 | — |
| Lösungsmittel | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Produkt | 5-(4-Methylpiperazinyl)-2-nitrobenzenecarbonitrile | HCID 16102059 | — |
Reaktionsschritte
5-Fluoro-2-nitrobenzenecarbonitrile (1.02 eq) and N-methylpiperazine, (1.0 eq) were dissolved in NMP. Triethylamine (2.1 eq) was added, and the resulting solution heated at 100° C. for 1 hour. The solution was cooled to room temperature and poured into H2O. A precipitate formed which was filtered to yield the desired product as a green solid. LC/MS m/z 247.3 (MH+), Rf 1.46 minutes.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US06605617B2 |
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| Quelldatensatz | uspto-grants-2003_08 |
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| ORD ID | ord-53df55582943408cafa0c461ad6b6887 |
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| Quellennotiz | uspto-grants-2003_08 |
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