1-Benzyl-4-hydroxy-3-isobutylpiperidine → HCID 21973782, Verbindung
Reaktionsgleichung
C([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH:10]([CH2:15][CH:16]([CH3:18])[CH3:17])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[OH-].[Pd+2].[OH-]>[OH:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH:10]1[CH2:15][CH:16]([CH3:18])[CH3:17]Komponenten
5
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
A mixture of 1-benzyl-4-hydroxy-3-isobutylpiperidine (0.63 g, 2.5 mmole) and 20% palladium hydroxide (0.1 g) in methanol (20 ml) was stirred in hydrogen atmosphere (1 atm.) for 48 hr at 35° C. Catalyst was filtered off, washed with methanol, filtrate was concentrated to dryness to give 4-hydroxy-3-isobutylpiperidine as oil. Yield 0.35 g (91%), C9H19NO, m/z 158 (M+1).
Aufarbeitung
- filtrationCatalyst was filtered off
- washwashed with methanol, filtrate
- concentrationwas concentrated to dryness
Quellen und Nachweise
- ORD-Eintrag
- ord-03d6d9f5b0ab4494b103241c2920734f
- Quelldatensatz
- uspto-grants-2003_08
- Patentnummer
- US06608078B2
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