2-Nitropropane → HCID 54195305, Verbindung

HRID 396358Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 396358
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:12]=[C:11]([CH:13]=[O:14])[C:10]2[C:5](=[C:6]([C:15]([F:18])([F:17])[F:16])[CH:7]=[CH:8][CH:9]=2)[N:4]=1.[N+:21]([CH:24]([CH3:26])[CH3:25])([O-:23])=[O:22]>C(Cl)Cl>[N+:21]([C:24]([CH:13]([C:11]1[C:10]2[C:5](=[C:6]([C:15]([F:18])([F:16])[F:17])[CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]([C:2]([F:19])([F:1])[F:20])[CH:12]=1)[OH:14])([CH3:26])[CH3:25])([O-:23])=[O:22]

Komponenten

4

Edukt 2

HCID 3982-NitropropaneHCID 122545692,8-Bis(trifluoromethyl)-4-quinolinecarboxaldehyde

Produkt 1

HCID 54195305HCID 54195305, VerbindungAusbeute 51 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 2,8-bis(trifluoromethyl)-4-quinolinecarboxaldehyde (200 mg, 0.85 mmol), 2-nitropropane (0.1 mL, 1.1 mmol) and Amberlyst 21 resin (200 mg) was stirred at room temperature for 17 h, treated with CH2Cl2 (3 mL), filtered to remove the resin, the filtrate concentrated in vacuo to give a viscous oil which was crystallised from heptane to give a white solid which was recrystallised (ether/heptane) to give the product (140 mg, 51%) as a white crystalline solid: IR νmax (Nujol)/cm−1 3484, 2923, 1544, 1311, 1134 and 780; NMR δH (400 MHz, CDCl3) 1.37 (3H, s), 1.54 (3H, s), 3.03 (1H, d, J 4.5 Hz),6.36 (1H, d, J 4.4 Hz), 7.80 (1H, t, J 8.1 Hz), 8.07 (1H, s), 8.21 (1H, d, J 7.1 Hz) and 8.44 (1H, d, J 8.5 Hz).

Aufarbeitung

  1. filtrationfiltered
  2. customto remove the resin
  3. concentrationthe filtrate concentrated in vacuo
  4. customto give a viscous oil which
  5. customwas crystallised from heptane
  6. customto give a white solid which
  7. customwas recrystallised (ether/heptane)

Quellen und Nachweise

ORD-Eintrag
ord-888e26de11314ac7a286a949bac880fe
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06608085B1

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