Thionyl Chloride → 3,5-Dichloro-4-fluorobenzoyl chloride

HRID 39643Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 39643
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:12])[C:10]=1[F:11])[C:5](O)=[O:6].S(Cl)([Cl:15])=O>CN(C=O)C.C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:12])[C:10]=1[F:11])[C:5]([Cl:15])=[O:6]

Komponenten

5

Edukt 2

HCID 24386Thionyl ChlorideHCID 199713033,5-Dichloro-4-fluorobenzoic acid

Produkt 1

HCID 196123793,5-Dichloro-4-fluorobenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

3,5-dichloro-4-fluorobenzoic acid was refluxed with >1 equivalent of thionyl chloride and one drop of DMF neat or as a solution in CHCl3. The solvent and volatile by-products were removed in vacuo to provide 3,5-dichloro-4-fluorbenzoyl chloride.

Aufarbeitung

  1. customThe solvent and volatile by-products were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-79e046e26e75425fb7e82c82a5c76a94
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524948B2

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