1-Bromo-3-chloropropane → HCID 69484213, Verbindung

HRID 397230Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 397230
[CH2:1]([N:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[Br:18][CH2:19][CH2:20][CH2:21][Cl:22]>CO>[Br-:18].[Cl:22][CH2:21][CH2:20][CH2:19][N+:13]1([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH2:14][CH2:15][CH2:16][CH2:17]1

Komponenten

4

Edukt 2

HCID 80061-Bromo-3-chloropropaneHCID 3732021Pyrrolidine, 1-dodecyl-

Produkt 1

HCID 69484213HCID 69484213, VerbindungAusbeute 64,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

47 g pyrrolidine, 149.5 g 1-bromododecane and 83 g potassium carbonate were added to 560 mL acetone. The reaction mixture was heated at 55° C. for 24 hr, then filtered. Solvent was removed from the filtrate, yielding 92 g N-dodecylpyrrolidine. 80 g N-dodecylpyrrolidine and 52.6 g 1-bromo-3-chloropropane were dissolved in 133 mL methanol and the reaction mixture was heated at 65° C. for 18 hr. After cooling to room temperature, methanol was removed under reduced pressure. The residue was poured into 2 L diethylether with stirring and the mixture was allowed to stand for another 6 hr. The white precipitate thus formed was filtered and was dried at 40° C. under a vacuum for 24 hr yielding 85 g (3-chloropropyl)dodecylpyrrolidinium bromide as a white solid.

Aufarbeitung

  1. temperatureAfter cooling to room temperature
  2. custommethanol was removed under reduced pressure
  3. additionThe residue was poured into 2 L diethylether
  4. customThe white precipitate thus formed
  5. filtrationwas filtered
  6. customwas dried at 40° C. under a vacuum for 24 hr

Quellen und Nachweise

ORD-Eintrag
ord-c722e517ae5f4e87b1002645587937d1
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610283B1

Notizen zur Reaktion

Wird geladen…