Hydrochloric Acid → (S)-2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethylamine hydrochloride

HRID 397322Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 397322
C(OC(=O)[NH:7][C@@H:8]([CH3:26])[CH2:9][C:10]1[C:18]2[CH:17]=[C:16]([O:19][CH:20]3[CH2:22][CH2:21]3)[CH:15]=[CH:14][C:13]=2[N:12]2[CH2:23][CH2:24][CH2:25][C:11]=12)(C)(C)C.[ClH:28]>C(OCC)(=O)C>[ClH:28].[CH:20]1([O:19][C:16]2[CH:15]=[CH:14][C:13]3[N:12]4[CH2:23][CH2:24][CH2:25][C:11]4=[C:10]([CH2:9][C@@H:8]([NH2:7])[CH3:26])[C:18]=3[CH:17]=2)[CH2:21][CH2:22]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 69363623(S)-[2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 21355889(S)-2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethylamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

A solution of 11.81 g (S)-[2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethyl]-carbamic acid tert-butyl ester in 120 mL of a 2.26 M solution of hydrochloric acid in ethyl acetate was stirred at room temperature for 2 h. The resulting suspension was diluted with 120 mL ethyl acetate and the product collected by filtration, washed with ethyl acetate and dried to constant weight under high vacuum to yield 8.65 g (S)-2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethylamine hydrochloride as white crystals melting at 214-217° C.

Aufarbeitung

  1. filtrationthe product collected by filtration
  2. washwashed with ethyl acetate
  3. customdried to constant weight under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-cae8b87ba305480e97f6a9ed922b281e
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610685B2

Notizen zur Reaktion

Wird geladen…