Ammonia → 2-(1-Tetrazolyl)benzylamine

HRID 397515Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 397515
[N:1]1([C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[C:8]#[N:9])[CH:5]=[N:4][N:3]=[N:2]1.N>C(O)C.[Ni]>[N:1]1([C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[CH2:8][NH2:9])[CH:5]=[N:4][N:3]=[N:2]1

Komponenten

5

Edukt 2

HCID 222AmmoniaHCID 218662732-(1H-Tetrazol-1-YL)benzonitrile

Produkt 1

HCID 111596142-(1-Tetrazolyl)benzylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2-Tetrazol-1-yl-benzonitrile (1.3 g, 7.6 mmol) in ethanol saturated with ammonia (125 ml) was stirred in the presence of Raney nickel (50% slurry in water, washed with ethanol, catalytic amount) under a hydrogen atmosphere overnight. The reaction mixture was filtered over celite and concentrated to give 2-Tetrazol-1-yl-benzylamine; 1H NMR (CDCl3, 400 MHz) δ9.28 (s, 1H), 7.59 (m, 2H), 7.47 (m, 2H), 3.70 (s, 2H).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered over celite and
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-312f3bb1713b49e68ef2c9ab3ea52b0c
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610701B2

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