Trifluoroacetic acid → HCID 59397877, Verbindung
Reaktionsgleichung
[O:1]=[C:2]([NH:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=1)[CH2:3][N:4]([CH:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][N:20]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[N:23]=[CH:22][C:21]2=[O:30])[CH2:14][CH2:13]1)C(=O)OC(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[O:30]=[C:21]1[CH:22]=[N:23][C:24]2[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:20]1[CH2:19][CH2:18][N:15]1[CH2:16][CH2:17][CH:12]([NH:4][CH2:3][C:2]([NH:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=2)=[O:1])[CH2:13][CH2:14]1Komponenten
4
Versuchsvorschrift
To 3 mL of a dichloromethane solution containing 0.26 g of tert-butyl (2-oxo-2-(pyridin-2-ylamino)ethyl)(1-(2-(2-oxoquinoxalin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, 3 mL of trifluoroacetic acid was added and stirred at room temperature for 1 hour. The solvent was removed under reduced pressure, chloroform and water were added, and adjusted to pH 11 with 20% aqueous sodium hydroxide solution. The organic layer was separated, and the aqueous layer was extracted with chloroform. The organic layer and extracts were combined, washed sequentially with water and aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to give 0.20 g of N2-(1-(2-(2-oxoquinoxalin-1(2H)-yl)ethyl)piperidin-4-yl)-N-(pyridin-2-yl)glycinamide as a light brown oil.