HCID 23444959, Verbindung → Benzenamine, 3-(1,1-difluoroethyl)-4-fluoro-

HRID 397917Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 397917
[F:1][C:2]([C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:6]=1[F:14])([F:4])[CH3:3]>CO>[F:4][C:2]([C:5]1[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:6]=1[F:14])([F:1])[CH3:3]

Komponenten

3

Edukt 1

HCID 23444959HCID 23444959, Verbindung

Produkt 1

HCID 23445006Benzenamine, 3-(1,1-difluoroethyl)-4-fluoro-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-(1,1-difluoro-ethyl)-1-fluoro-4-nitro-benzene (10.4 g, 50.6 mmol) in methanol (200 ml) palladium on carbon (10%, 4 g) was added and the resulting mixture was hydrogenated for 2 h at 20° C. After filtration of the catalyst the solvent was evaporated to yield the title compound as a yellow semi solid mass. (8.5 g, 96%). MS: m/e=175 (M+).

Aufarbeitung

  1. filtrationAfter filtration of the catalyst the solvent
  2. customwas evaporated

Quellen und Nachweise

ORD-Eintrag
ord-91f15c36b62f4479a0122d0f5d63f4cb
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610723B2

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