Phenol → Di-tert-butyl ether

HRID 398022

Reaktionsgleichung

[C:1]1([OH:7])[CH:6]=CC=C[CH:2]=1.CNC(=NC)O[C:12]([CH3:15])([CH3:14])[CH3:13].[C:18](OCC)(=O)C.CCCCCC>>[C:12]([O:7][C:1]([CH3:2])([CH3:6])[CH3:18])([CH3:15])([CH3:14])[CH3:13]

Komponenten

Edukt 3

HCID 996Phenol

HCID 21226206Ethyl acetate hexane

HCID 23001675N,N'-dimethyl-O-t-butylisourea

Produkt 1

HCID 22541Di-tert-butyl etherAusbeute 15 %

Versuchsvorschrift

Following a procedure analogous to (3b), the phenol from (3a) (270 mg, 0.97 mmol) was reacted with N,N′-dimethyl-O-t-butylisourea. Silica gel chromatography (ethyl acetate-hexane, 20:80) gave the t-butyl ether (50.2 mg, 15%) as a 1:1 mixture of two isomers. MS found: (M+H)+=334.

Quellen und Nachweise

ORD-Eintrag: ord-06a1d31e4388451ab0e3ab6eef91a634
Quelldatensatz: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06610731B2

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