Methanol → Methyl 2-((4-hydroxyphenyl)amino)acetate
Reaktionsgleichung
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.[CH3:13]O>>[CH3:13][O:11][C:10](=[O:12])[CH2:9][NH:8][C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=1Komponenten
3
Versuchsvorschrift
The p-hydroxy phenyl glycine (74.0 g, 442 mmol) was suspended in methanol (500 mL), cooled in an ice bath and HCl (gas) was bubbled through the reaction mixture for 20 minutes, to give a clear solution. The reaction was stirred at rt for 48 h, concentrated in vacuo to give an oil which was triturated with ethyl ether to give the p-hydroxy phenyl glycine methyl ester (95.8 g, 99%) as a white powder. MS found: (M+H)+=182.
Aufarbeitung
- temperaturecooled in an ice bath
- customHCl (gas) was bubbled through the reaction mixture for 20 minutes
- customto give a clear solution
- concentrationconcentrated in vacuo
- customto give an oil which
- customwas triturated with ethyl ether
Quellen und Nachweise
- ORD-Eintrag
- ord-49d8304cdbec4ea2a75f2c2f5b3084f4
- Quelldatensatz
- uspto-grants-2003_08
- Patentnummer
- US06610731B2
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