Chlorotrimethylsilane → 2-Methyl-N,N-bis(trimethylsilyl)pyrimidin-4-amine

HRID 398691

Reaktionsgleichung

Reaktionsgleichung von HRID 398691
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[N:3]=1.Cl[Si:10]([CH3:13])([CH3:12])[CH3:11]>C[Si](C)(C)N[Si](C)(C)C>[CH3:11][Si:10]([CH3:13])([CH3:12])[N:1]([C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[N:3]=1)[Si:10]([CH3:13])([CH3:12])[CH3:11]

Komponenten

4

Edukt 2

HCID 6397ChlorotrimethylsilaneHCID 2957632-Methylpyrimidin-4-amine

Produkt 1

HCID 223152262-Methyl-N,N-bis(trimethylsilyl)pyrimidin-4-amineAusbeute 614,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13838HexamethyldisilazaneLösungsmittel

Versuchsvorschrift

A slurry of 4-amino-2-methylpyrimidine (2.04 g, 18.69 mmol) in 1,1,1,3,3,3-hexamethyldisilazane (40 mL) and chlorotrimethylsilane (0.36 mL, 2.8 mmol) was heated at 150° C. for 8 h. At this time, the reaction mixture was close to a homogeneous solution. The resulting slightly orange solution was then filtered to remove any remaining solids. The filtrate was concentrated in vacuo to afford 4-(1,1,1,3,3,3-hexamethyl-disilazan-2-yl)-2-methyl-pyrimidine as an off-white solid (2.18 g).

Aufarbeitung

  1. customAt this time, the reaction mixture was close to a homogeneous solution
  2. filtrationThe resulting slightly orange solution was then filtered
  3. customto remove any remaining solids
  4. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f296f1bbe65447f89db266ae0b3412b9
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610846B1

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