Isoindoline → HCID 10638841, Verbindung
Reaktionsgleichung
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([F:14])=[C:10]2[C:6]=1[CH2:7][C:8](=[O:15])[NH:9]2.[CH2:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][NH:17]1>>[CH2:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][N:17]1[CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([F:14])=[C:10]2[C:6]=1[CH2:7][C:8](=[O:15])[NH:9]2Komponenten
3
Versuchsvorschrift
4-(2-Chloroethoxy)-7-fluoro-1,3-dihydro-indol-2-one was reacted with isoindoline in the same manner described for intermediate 16 to afford the title compound in 75% yield as a thick oil. The fumarate salt was prepared in ethanol: mp 210°-212° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-252cb9b7741d44db84ddf1af7599a548
- Quelldatensatz
- uspto-grants-1998_10
- Patentnummer
- US05817690
Notizen zur Reaktion
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