Thionyl Chloride → 3-Chloro-1-methyl-1h-pyrazole-5-carbonyl chloride

HRID 399191

Reaktionsgleichung

Reaktionsgleichung von HRID 399191
[Cl:1][C:2]1[CH:6]=[C:5]([C:7](O)=[O:8])[N:4]([CH3:10])[N:3]=1.S(Cl)([Cl:13])=O>C1C=CC=CC=1>[Cl:1][C:2]1[CH:6]=[C:5]([C:7]([Cl:13])=[O:8])[N:4]([CH3:10])[N:3]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 189704593-chloro-1-methyl-1H-pyrazole-5-carboxylic acid

Produkt 1

HCID 189704623-Chloro-1-methyl-1h-pyrazole-5-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

100 g of 3-chloro-1-methyl-5-pyrazole-carboxylic acid (the Compound No. 4.1 (a) of the present invention) were suspended in 200 ml of benzene, and 150 ml of thionyl chloride were added thereto dropwise. Then, the mixture was heat-refluxed for 4 hours. The reaction mixture was allowed to cool, and the solvent was then distilled off under reduced pressure. The resulting residue was distilled under reduced pressure to obtain 103 g of the intended 3-chloro-1-methyl-5-pyrazolecarbonyl chloride.

Aufarbeitung

  1. temperatureThen, the mixture was heat-refluxed for 4 hours
  2. temperatureto cool
  3. distillationthe solvent was then distilled off under reduced pressure
  4. distillationThe resulting residue was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-14124bb4c18a40d087add9a7a5ae0295
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05817829

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