Methanol → Methyl 4-methoxypyridine-2-carboxylate

HRID 399478

Reaktionsgleichung

Reaktionsgleichung von HRID 399478
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([O:10][CH3:11])=[O:9])[CH:3]=1.[Na].[CH3:13][OH:14]>>[CH3:13][O:14][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([O:10][CH3:11])=[O:9])[CH:3]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 820890Methyl 4-ChloropicolinateHCID 5360545Sodium

Produkt 1

HCID 1519345Methyl 4-methoxypyridine-2-carboxylate

Versuchsvorschrift

A mixture of methyl 4-chloropyridine-2-carboxylate (3.7 g), sodium metal (0.5 g) and methanol (100 ml) was stirred and heated to reflux for 8 hours. The mixture was evaporated and the residue was partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated to give methyl 4-methoxypyridine-2-carboxylate (3 g).

Aufarbeitung

  1. temperatureheated
  2. temperatureto reflux for 8 hours
  3. customThe mixture was evaporated
  4. customthe residue was partitioned between ethyl acetate and water
  5. dry with materialThe organic phase was dried (MgSO4)
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-20b68bca3eea4b289fb28d8fe1e448c8
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05821246

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