5-Chloro-2-methylphenyl isothiocyanate → 2-[3-(5-Chloro-2-methylphenyl)-1-phenyl-thioureido]-acetic acid ethyl ester

HRID 399601

Reaktionsgleichung

Reaktionsgleichung von HRID 399601
[CH2:1]([O:3][C:4](=[O:13])[CH2:5][NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2].[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([CH3:24])=[C:19]([N:21]=[C:22]=[S:23])[CH:20]=1>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:13])[CH2:5][N:6]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:22]([NH:21][C:19]1[CH:20]=[C:15]([Cl:14])[CH:16]=[CH:17][C:18]=1[CH3:24])=[S:23])[CH3:2]

Komponenten

4

Edukt 2

HCID 295195-Chloro-2-methylphenyl isothiocyanateHCID 75190N-Phenylglycine ethyl ester

Produkt 1

HCID 543145622-[3-(5-Chloro-2-methylphenyl)-1-phenyl-thioureido]-acetic acid ethyl esterAusbeute 94,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A mixture of N-phenyl glycine ethyl ester (8.95 g), 5-chloro-2-methylphenyl-isothiocyanate (9.18 g), and chloroform (200 mL) was heated at reflux for 24 hours. The solvent was evaporated. The residue was crystallized from ethyl acetate/hexane mixture. The solid was collected and dried to give 17.2 g of 2-[3-(5-chloro-2-methylphenyl)-1-phenyl-thioureido]-acetic acid ethyl ester as a white solid, m.p. 148°-1500° C. Anal. Calcd. for. C18H19Cl N2O2S: C, 59.58; H, 5.28; N, 7.72. Found: C, 59.79; H, 5.38; N, 7.65. Mass spectrum (EI, M.+) m/z 262/264.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 24 hours
  3. customThe solvent was evaporated
  4. customThe residue was crystallized from ethyl acetate/hexane mixture
  5. customThe solid was collected
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-036d5124d7f84efeabd3ccee3b393eec
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05821372

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