Hydrogen chloride-ethyl acetate → HCID 67537667, Verbindung

HRID 39963

Reaktionsgleichung

Reaktionsgleichung von HRID 39963
[C:1]1([C:7]#[C:8][CH2:9][N:10]([CH2:31][C:32]#[C:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][N:19]3[C:28]4[C:23](=[CH:24][CH:25]=[C:26]([F:29])[CH:27]=4)[N:22]=[CH:21][C:20]3=[O:30])[CH2:13][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:40].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:40].[C:34]1([C:33]#[C:32][CH2:31][N:10]([CH2:9][C:8]#[C:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][N:19]3[C:28]4[C:23](=[CH:24][CH:25]=[C:26]([F:29])[CH:27]=4)[N:22]=[CH:21][C:20]3=[O:30])[CH2:13][CH2:12]2)[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Komponenten

4

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593983021-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one

Produkt 1

HCID 67537667HCID 67537667, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To 5 mL of a chloroform solution containing 132 mg of 1-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one, 0.5 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 141 mg of 1-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one hydrochloride as a pale brown solid.

Aufarbeitung

  1. additionwas added
  2. customThe solvent was removed under reduced pressure, ethyl acetate
  3. additionwas added
  4. filtrationthe resulting solid was filtered

Quellen und Nachweise

ORD-Eintrag
ord-909734bbe43f478ebf7f2169d2ef9646
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524738B2

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