Hydrogen chloride-ethyl acetate → HCID 67539252, Verbindung

HRID 39965Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 39965
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](=[O:32])[N:9]2[CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][CH2:21][C:22]3[CH:26]=[C:25]([C:27]4[S:28][CH:29]=[CH:30][CH:31]=4)[O:24][N:23]=3)[CH2:16][CH2:15]2)=[CH:4][CH:3]=1.[ClH:33].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:33].[F:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](=[O:32])[N:9]2[CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([NH:20][CH2:21][C:22]3[CH:26]=[C:25]([C:27]4[S:28][CH:29]=[CH:30][CH:31]=4)[O:24][N:23]=3)[CH2:18][CH2:19]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593983557-fluoro-1-(2-(4-((5-(thiophen-2-yl)isoxazol-3-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one

Produkt 1

HCID 67539252HCID 67539252, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To 10 mL of a chloroform solution containing 232 mg of 7-fluoro-1-(2-(4-((5-(thiophen-2-yl)isoxazol-3-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 247 mg of 7-fluoro-1-(2-(4-((5-(thiophen-2-yl)isoxazol-3-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride as a pale brown solid.

Aufarbeitung

  1. additionwas added
  2. customThe solvent was removed under reduced pressure, ethyl acetate
  3. additionwas added
  4. filtrationthe resulting solid was filtered

Quellen und Nachweise

ORD-Eintrag
ord-5f010581e86e408490ec9c18e4a28770
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524738B2

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