Methanol → 2-[3-(2-Cyanopyrrol-1-yl) benzoyl]guanidine hemisulfate

HRID 399871Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 399871
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:21])[NH2:20])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7].CO>C(OCC)(=O)C>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:20])[NH2:21])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:20])[NH2:21])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 189451892-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine

Produkt 1

HCID 1317208902-[3-(2-Cyanopyrrol-1-yl) benzoyl]guanidine hemisulfate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Conc. sulfuric acid (0.42 ml) was added to a mixture of 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine (2.0 g) and methanol (20 ml), and the mixture was stirred for 30 minutes at ambient temperature. To the mixture was added ethyl acetate (20 ml), and the isolated precipitate was collected by filtration. The precipitate was recrystallized from methanol-water to give 2-[3-(2-cyanopyrrol-1-yl) benzoyl]guanidine hemisulfate (1.53 g).

Aufarbeitung

  1. filtrationthe isolated precipitate was collected by filtration
  2. customThe precipitate was recrystallized from methanol-water

Quellen und Nachweise

ORD-Eintrag
ord-97023756ec204dcb8260329331a5d280
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05824691

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