Methanesulfonic Acid → 2-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine methanesulfonate

HRID 399878Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 399878
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:21])[NH2:20])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7].C(OCC)(=O)C>CO>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:20])[NH2:21])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7]

Komponenten

5

Edukt 3

HCID 6395Methanesulfonic AcidHCID 8857Ethyl AcetateHCID 189451892-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine

Produkt 1

HCID 867532352-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine methanesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methanesulfonic acid (0.8 ml) was added to a mixture of 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine (2.0 g) in methanol (20 ml) and the mixture was stirred for 30 minutes at ambient temperature. To the mixture was added ethyl acetate (20 ml) and isolated precipitate was collected by filtration. The precipitate was recrystallized from water to give 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine methanesulfonate (1.48 g).

Aufarbeitung

  1. customisolated precipitate
  2. filtrationwas collected by filtration
  3. customThe precipitate was recrystallized from water

Quellen und Nachweise

ORD-Eintrag
ord-4f19722ec46d44dcba0ab3ec1beba662
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05824691

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