Ethyl formate → 2-hydroxy-3-ethoxycarbonyl-7-benzyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine
Reaktionsgleichung
[CH2:1]([N:8]1[CH2:14][CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:16]([O:18][CH2:19][CH3:20])=[O:17].[C:21](OCC)(=O)[CH2:22][C:23]([NH2:25])=[O:24].[H-].[Na+]>>[OH:24][C:23]1[C:22]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:21][C:12]2[CH2:13][CH2:14][N:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH2:9][CH2:10][C:11]=2[N:25]=1Komponenten
5
Versuchsvorschrift
Prepared from 1-benzyl-hexahydro-4-azepinone with ethyl formate and ethyl malonamate in the presence of sodium hydride.