Methanol → Methyl 2-methylisonicotinate

HRID 400444

Reaktionsgleichung

Reaktionsgleichung von HRID 400444
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([OH:7])=[O:6].[CH3:11]O>Cl>[CH3:11][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][N:10]=[C:2]([CH3:1])[CH:3]=1

Komponenten

4

Edukt 2

HCID 887MethanolHCID 27628212-Methylpyridine-4-carboxylic acid

Produkt 1

HCID 11542811Methyl 2-methylisonicotinate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

5 g 2-methyl-isonicotinic acid was stirred 24 h at 50° C. in 150 mL 1.3 mol/L HCl in methanol. The solvent was removed and water was added to the residue. The mixture was basified with saturated sodiumhydrogencarbonate solution and extracted with ethylacetate. The organic layer was dried with magnesiumsulfate and evaporated to give 4.5 g of the desired product.

Aufarbeitung

  1. customThe solvent was removed
  2. additionwater was added to the residue
  3. extractionextracted with ethylacetate
  4. dry with materialThe organic layer was dried with magnesiumsulfate
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-2e0df64ed7db4a9abe1c7b7222727b7c
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08741892B2

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